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Custom Synthesis Services
Lead
compounds/Precursor/Intermediate/Derivatives/Impurities/References
/Metabolite/Substrates/Inhibitors/Activators/Fluorescent dyes, ...
Elastic additives/Surface modification/Cosmetics/Paints/Ink solvents/Lubricants,
...
Custom Synthesis & Services
provides complete strategic solutions to improve the laboratory efficiency and
throughput, with optimized resource integration and interdiscipline co-operations.
Organic Synthesis Services
https://en.wikipedia.org/wiki/Chemical_synthesis#Organic_synthesis
Organic synthesis is a special branch of chemical synthesis dealing with the
synthesis of organic compounds. In the total synthesis of a complex product it
may take multiple steps to synthesize the product of interest, and inordinate
amounts of time.
Skill in organic synthesis is prized among chemists and the synthesis of
exceptionally valuable or difficult compounds has won chemists such as Robert
Burns Woodward the Nobel Prize for Chemistry. |
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If a chemical synthesis starts from basic laboratory
compounds and yields something new, it is a purely synthetic process. If it
starts from a product isolated from plants or animals and then proceeds to new
compounds, the synthesis is described as a semisynthetic process.
Biosynthesis :
https://en.wikipedia.org/wiki/Biosynthesis
Our team encompasses professional
experienced chemists and biologists who provide very extensive and professional
Custom Synthesis supports. |
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Biological & Pharmaceutical fields:
Lead compounds, Precursor Intermediate, Derivatives, Impurities, References,
Metabolite, Substrates, Inhibitors, Activators, Fluorescent dyes, ...
Fine
Chemicals and Livelihoods:
Elastic additives, Surface modification, Cosmetics, Paints, Ink solvents,
Lubricants, ... |
Technology application
Lab, Pilot & Process scales
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From milligram(Labs) to gram(Pilot) quantities of customized organic
compounds can be produced in our own and partner's facility, and for
kilogram(Process) manufacturing sacles with our industrial partners.
Simply provide the chemical name, structure or CAS number and with your desired
purity level, then our experienced scientific team will evaluate and design the
organic synthetic route based on our extensive Molarcular Libraries search,
Structure Optimization experiences and the seamless team works from our
professional partners. |
Impovements
For existing items & project
impovements of Performance, C/P and Environmental Sustainability, the more
information you can provide us, the more the possibility a significant better
production process and solution that could be implemented with shorter
turnaround time and more competitively priced, performance, C/P and
environmental sustainability.
Information includes, for example :
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1. Any known
literature methods
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2. Your own existing synthetic route
3. Experimental details,
4. Reaction times,
5. Temperatures,
6. Solvents and concentrations
7. Work-up procedures
,
8. Purification methods,
9. Yields and any analytical data. |
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Service Optimaiztion and Development
Our customized
services is optimized for short and long term co-operational and developmental
requirements, including:
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1.
Periodic/Routine Project
2. Specific technology development
3. Specific
product development
4. Systematic technology research and development
5. Systematic product development
6. Integrated synthetic process solution development
7.
Special dosage form development . |
Structure Analysis
Purification Advantages
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https://en.wikipedia.org/wiki/Chromatography
Target species purities is must for valid and precise
structure analysis, and is also for research, quality control and proceess
requirements.
Our group is the most sophisticated, the largest R&D and manufacturing,
technology applications and service team in Asia for the Downstream Processing
Solution with gloabl class equipments and materails.
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Our equipments are internationally comparable system with
GE, Novasep, Agilent and other products (local performance is even better).
http://www.chromnet.net/Downstream Processing Solution_English.aspx
And for Chromatography separation media, we are key co-operators of the global
Top manufacturors:
The world's only patented 'uniform particle size microspheres'
http://www.chromnet.net/NanoMicroSpheres_English.aspx
The world's most advanced ultra-high performance spherical silica based
chromatography media
Https://www.kromasil.com
Third-Generation Argarose based chromatography media
HHttp://www.bio-works.com/
Team Partners
Jin Sun Industrial Co., Ltd. (JSC)
http://www.jinsunchem.com/
Dr. Chen and team members with the background of new drug development and
synthesis method development and research, have assisted many medical and
pharmaceutical institutes and manufacturers to assist in the customized
synthesis.
The JSC synthesis team has more than 10 years of experience in the synthetic
field, developing services from early stage initialization to commercial
production that provides customized services through expertise and special
specifications of materials , based on professional technology, knowledge and
capabilities.
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With nearly 10 years of experience in the synthesis of polyethylene glycol
(PEGs) derivatives in the pharmaceutical industry, the JSC offers a variety of
high purity polyethylene glycol (PEG) derivatives, Pegylated nanoparticles
resembling liposomes and polymeric micelles, and PEG hydrogels, PEG linkers that
can perform a variety of applications.
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Project Co-operators
Customized Service Examples
The de novo(scratch) or partial synthesis, modification,
and formulation optimizations are the main goals of customized services.
1. Polyethylene glycol (PEG) modification and
synthesis:
https://en.wikipedia.org/wiki/Polyethylene_glycol
PEG refers to an oligomer or polymer of ethylene oxide.
Because different applications require different polymer chain lengths, PEG
tends to refer to oligomers and polymers with a molecular weight below 20,000
g/mol.
Polyethylene glycol is ethylene oxide prepared by polymerization and is
commercially available in a broad molecular weight range of 300 g/mol to
10,000,000 g/mol. it contains linear, branched, multi-armed, mono-functional,
and polyfunctional types, and the structure can be bound to the terminal, such
as maleimide, aldehyde, oxyamine, etc., and their molecular weight (MW) is 350
to 40000 range.
Also provides customize modofication of the API on the carrier for the
pharmacokinetics scientists.
Liposomes and polymeric micelles, carrier hydrogels and carrier linkers can
perform a wide variety of applications.
2. Ionic liquid (IL) modification and synthesis
https://en.wikipedia.org/wiki/Ionic_liquid
Ionic liquids are generally moderate to poor electrical conductors, non-ionized
(e.g., non-polar), highly viscous, and often exhibit low vapor pressures.
Their other properties are diverse: many have low flammability, thermal
stability, have a wide liquid area, and have good solvation properties for polar
and non-polar compound ranges.
Miscible solvents with water or organic ionic liquids vary with the choice of
side chain length and anion of the cation. They can be functionalized to act as
acids, bases or ligands and are precursor salts in the preparation of stable
carbenes. Due to its unique properties, ionic liquids are attracted in many
fields, including more and more attention to organic chemistry,
electrochemistry, catalysis, physical chemistry and engineering..
3. Synthesis of other derivatives:
https://en.wikipedia.org/wiki/Heterocyclic_compound
For Heterocyclic compounds, natural derivatives, drug-like compounds, etc.
Synthesis is the purpose of a chemical reaction to obtain a product or several
products. This occurs through physical and chemical manipulations and usually
involves one or more reactions, started by selecting a compound that is known to
be a reagent.
Various reaction types can be used to synthesize products or intermediates.
Many reactions require some form of post-processing procedure before the final
product is separated. The amount of product in chemical synthesis is the
reaction yield. In general, the chemical yield is expressed as the weight in
grams or as a percentage of the total theoretical amount of product that can be
produced.
High lighted Formulation Technology
These products already have a
certain status in the market, and many of our customers have chosen it because
of its versatility and ease of understanding.
Michelle (Microvesicle),
Liposome,
Microcapsule,
Solid Dosage,
Liquid Dosage
Formulations are a very important part of pharmacy because they are essential
for ensuring that the active part of the ingredient is delivered to the correct
site at the right concentration and at the right rate.
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They need to have an acceptable taste, be stored for a sufficient period of
time, be safe and effective at the time of use, and be physically and chemically
stable enough to be transported from their place of manufacture to the hands of
the end consumer.
The well-designed formulation for a particular application is safer, more
effective, and more economical than any component used alone.
Colloidal
https://en.wikipedia.org/wiki/Colloid
The sol can be deposited on the upper substrate to form a thin film by
coating procedure etc. or be casted into a suitable container with the desired
shape (eg, ceramic, glass, fiber, film, aerogel) or for synthetic powders (eg
microspheres, nanospheres). Even small amounts of dopants, such as organic dyes
and rare earth elements, can be introduced into the sol and eventually uniformly
dispersed in the final product. It can be used as an investment casting material
in ceramic processing and manufacturing, or as a means for producing very thin
metal oxide thin films for various purposes.
Microparticle
https://en.wikipedia.org/wiki/Microparticle
Hollow Microspheres
Microspheres are small spherical particles with a diameter in the micrometer
range (usually 1 μm to 1000 μm). Glass, polymer and ceramic microspheres are
commercially available. Solids and hollow microspheres vary greatly in density
and are therefore used in different applications. Hollow microspheres are often
used as additives to reduce the density of the material.
Dihydride monomer - dianhydride
https://en.wikipedia.org/wiki/Hydride
Dihydrides are molecules with two anhydride functional groups. Examples
of dianhydrides: Pyromellitic dianhydride (PMDA), 3,3',4,4'-oxydicarboxylic
dianhydride (ODPA), 3,3',4,4'-benzophenonetetracarboxylic Dihydric anhydride
(BTDA), 4,4'-hexafluoroisopropylidene diacetate (6FDA), benzoquinone
tetracarboxylic dianhydride, ethylene tetracarboxylic dianhydride.
Polyanhydrides are a class of polymers characterized by the anhydride bond that
connect the repeating units of the polymer backbone chain.
Distribution products
1. Various types of bactericidal and
fungicidal agents (CMIT/MIT, BIT, MIT, OIT, IPBC, BNPD.....), long-acting
cationic anti-mildew inhibitors (PHMG), water treatment agents, water tanks
additives/SKAF, etc.
https://www.skchemicals.com/main.do
2.
The Organic, inorganic, metals and metal alloys, precious metal salts, metal
organic chemicals, polymer, nano, materials. Biochemistry, immunology,
antibodies, electrophoresis, pharmaceutical intermediates, laboratory equipment,
etc.
http://beantownchem.com/
3.
Acetone、Acetonitrile、Dichlorometane, Ethyl Acetate, Heptane, Hexane, IPA,
Methanol, MEK, NMP, THF, Water ...), DNA synthesis.
https://www.honeywell.com/industries/performance-materials-chemicals
Publications
1.
Regioselectivesynthesis of imidazo[1,5-a]quinoxalinesand methyl
Nphenylbenzimidateson an ionic liquid support. Chen, Li-Hsun; Kao, Chih-Hsien;
Dhole, Sandip; Barve, IndrajeetJ.; Shen, Li-Ching; Chung, Wen-Sheng; Sun,
ChungMing*. RSC Advances (2016), 6(80), 76123-76127.
2. A Novel Mechanistic Study on Ultrasound-Assisted, One-Pot Synthesis of
Functionalized Benzimidazo[2,1-b]quinazolin-1(1H)-ones. Chen, Li-Hsun;
Chung, Tsai-Wen; Narhe, Bharat D.; Sun, Chung-Ming*. ACS Combinatorial Science
(2016), 18(3), 162-169.
3. Parallel synthesis and biological evolution of quinic acid derivatives as
immunosuppressing agents against T-cell receptors. Huang, Chih-Yu; Chen,
Li-Hsun; Huang, Hsuan-Yu; Kao, Feng-Sheng; Lee, Yun-Ta; Selvaraju, Manikandan;
Sun, Chung-Ming*; Chen, Hueih-Min* , RSC Advances, (2015), 63 (5), 50801-50806.
4. Palladium-catalyzed regioselective synthesis of 2(2[Formula: see
text]biphenyl)benzimidazole through C-H activation. Chen, Li-Hsun;Wu, Tz-Yi;
Paike, Vijaykumar; Sun, Chung-Ming*. Molecular diversity(2013), 17(4), 641-649.
5. Enantioselective synthesis of (−)-(R) Silodosin by ultrasound-assisted
diastereomeric crystallization. Barve, Indrajeet J.; Chen, Li-Hsun; Wei, Patrick
C. P.; Hung, Jui-Te; Sun, Chung-Ming*. Tetrahedron, (2013), 69(13), 2834-2843.
6. Divergent ionic liquid supported synthesis of isolable guanidine linked
quinoxalinone and benzodiamine. Chen, Li-Hsun; Xu, Zhan-Hui; Lin, Chun-Chung;
Sun, ChungMing . Tetrahedron Letters, (2013), 54(6), 454-458.
7. Condensation-ring expansion reaction of [2.2.1]bicyclic carbinols with
para-substituted phenyl amines: application to the preparation of
[3.2.1]bicyclic N-aryl-1,2,3oxathiazolidine-2-oxide agents. Yang, Te-Fang*;
Chen, Li-Hsun; Kao, Li-Ta; Chuang, Chih-Hsiang; Chen, Yong-Yen. Journal of the
Chinese Chemical Society (Weinheim, Germany) (2012), 59(3), 378-388.
8. Traceless polymer-supported divergent synthesis of quinoxalinones by
microwave irradiation. Shen, Chien-Hung; Tseng, Chih-Chung; Tasi, Cheng-Hsun;
Shintre, Suhas A.; Chen, Li-Hsun; Sun, Chung-Ming*. Tetrahedron(2012), 68(18),
3532-3540.
9. Divergent synthesis of unsymmetrical annulated biheterocyclic compound
libraries: benzimidazole linked indolo-benzodiazepines/quinoxaline. Chen,
Li-Hsun; Chang, Chia-Mao; Salunke, Deepak B.; Sun, Chung-Ming*, ACS
Combinatorial Science (2011), 13(4), 391-398.
10. Soluble polymer supported divergent synthesis of tetracyclic benzene-fused
pyrazino/diazepino indoles: an advanced synthetic approach to bioactive
scaffolds. Lin, Po-Tsung; Salunke, Deepak B.; Chen, Li-Hsun; Sun, Chung-Ming*,
Organic & Biomolecular Chemistry (2011), 9(8), 2925-2937.
11. Microwave promoted simple, efficient and regioselective synthesis of
trisubstituted imidazo[1,2-a]benzimidazoles on soluble support. Chen, Li-Hsun;
Hsiao, Ya-Shan; Yellol, Gorakh S.; Sun, Chung-Ming*, ACS Combinatorial Science
(2011), 13(2), 112-119.
12. Selective reaction of camphor-derived exo-formyl [2.2.1]bicyclic carbinol
with alkyl primary amines: application to the preparation of new chiral
catalysts for asymmetric reduction of aryl ketones. Yang, Te-Fang*; Shen,
Chien-Hung; Hsu, Chi-Tung*; Chen, Li-Hsun; Chuang, Chih-Hsiang,
Tetrahedron(2010), 66(45), 8734-8738.
13. Multidisciplinary Synthetic Approach for Rapid Combinatorial Library
Synthesis of Triaza-Fluorenes. Hsiao, Ya-Shan; Yellol, Gorakh S.; Chen, Li-Hsun;
Sun, Chung-Ming*, Journal of Combinatorial Chemistry (2010), 12(5), 723-732.
14. Regio-and stereoselective rearrangements of formyl [2.2.1]bicyclic carbinols
in methanol. Yang, Te-Fang*; Tseng, Chih-Hao; Shen, Chien-Hung; Chen, Li-Hsun;
Kao, Li-Ta, Tetrahedron(2009), 65(47), 9854-9861.
15. Grignard reagent-promoted selective ring expansion and alkylation of formyl
borneol and isoborneol: a new route to highly substituted cyclopentanes. Yang,
Te-Fang*; Zhang, Zhong-Nian; Tseng, Chih-Hao; Chen, Li-Hsun, Tetrahedron
Letters(2005), 46(11), 19171920. .
Poster presentations
1. Liquid-phase divergent synthesis of unsymmetrical annulated biheterocyclic
compound libraries: Benzimidazolelinked indolobenzodiazepines/quinoxaline” in
the 10th International Symposium on Organic Reactions, Yokohama, Japan, 2011.
2. Ultrasound-Assisted Three-Component Synthesis of
4HPyridimido[2,1-b]BenzolesLibraries” Presented at the 9th International
Symposium on Organic Reactions, Chiayi, Taiwan, 2008.
3. Study on the Ring Expansion Reaction of Camphor-Derived
Formyl[2.2.1]bicyclicCarbinolwith Primary Amines”, Presented at the 9th
International Symposium on Organic Reactions, Chiayi, Taiwan, 2008. Oral
presentation: “Microwave-assisted Synthesis of Benzoimidazol-imidazo[1,2-a]
QuinoxalineBis-aryl Ring System as the VEGFR-targeted Cancer” in 2008 PST
Medicinal Chemistry Symposium, June 28-30, 2008, Si-Tou, Nan-Tou, Taiwan.
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